Wednesday, November 6, 2024
KCA Mentorship Meeting (by invitation only)2:00 PM - 6:30 PMWheat

Sponsored by Pfizer.

Moderator: Salvatore La Rosa, PhD

Thursday, November 7, 2024
KCA Mentorship Meeting (by invitation only)8:00 AM - 12:00 PMWheat

Sponsored by Pfizer.

Moderator: Salvatore La Rosa, PhD

AKCI Mentorship Lunch and Meeting (by invitation only)12:00 PM - 4:00 PMCommonwealth 1

Moderator: Brian Rini, MD, FASCO

Think Tank Meeting1:00 PM - 4:00 PMWheat

By invitation only.  Sponsored by Exelixis.

Registration Desk Open1:00 PM - 6:00 PM2nd Street Pre-function Hallway 
Pre-clinical/ Translational Session 14:00 PM - 5:15 PMCommonwealth Ballroom 2 & 3

The session will cover the RCC Therapeutic Landscape: preclinical models, emerging new therapeutics with a path to the clinic.

Chairs: Qing Zhang, PhD, M. Celeste Simon, PhD


Understanding and Optimizing Anti-Tumor Immunity in RCC: David Braun, MD, PhD


Presenter has requested their slides not be posted

 

Targeting the Dysfunctional SCL1A1/EAAT3 Transporter in Kidney Cancer: Abhishek Charkraborty, PhD

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Harnessing Metabolism to Treat Renal Cancer: M. Celeste Simon, PhD

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Targeting Acquired Resistance to HIF2⍺ Inhibition in Kidney Cancer: Qing Zhang, PhD
 

Presenter has requested their slides not be posted

 

Biological Insights from Resistance Mechanisms: James Brugarolas, MD, PhD

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Moderated Q & A

Pre-clinical/ Translational Session 25:30 PM - 6:45 PMCommonwealth Ballroom 2 & 3

This session will focus on RCC Genetic Evolution in Primary Tumor and Metastasis, advanced models and analyses to identify innovative drug modalities.

Chairs: Marie Carlo,MD, Samra Turajlic, MD


Transcriptional evolution of ccRCC: Samra Turajlic, MD

 

Presenter has requested their slides not be posted


Cell Competition Shapes Metastatic Latency and Relapse in RCC: Srinivas Malladi, PhD

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Mapping dependencies across kidney cancer subtypes: Srinivas Viswanathan, MD, PhD

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KEAP1/NRF2 Pathway Somatic and Germline Mutations and Clinical Implications in RCC: Marie Carlo, MD
 

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Q&A and Wrap- Up

KCA Clinical Advisory Board Meeting (invitation only)6:00 PM - 8:00 PMWheat

Moderators:

Lauren Wood, RN, MSN, OCN

Nancy Moldawer, RN, MSN

Faculty Networking Event8:30 PM - 10:00 PMRooftop

By invitation only.  Sponsored by Pfizer.

Friday, November 8, 2024
Rise & Shine Yoga6:00 AM - 7:45 AMCopper

Sponsored by Genentech.

Due to overwhelming response, two sessions will be held.  The first is 6:00-6:45AM and second 7:00-7:45AM.

Registration Desk Open6:30 AM - 6:15 PM2nd Street Pre-function Hallway 
Young Investigators Session/ Breakfast7:00 AM - 8:00 AMCommonwealth Ballroom 2 & 3

Sponsored by Pfizer.

Moderators: Tian Zhang, MD, MHS, Lauren Meehos Machos, MPH
 

Expert Panelists:

Brian Rini, MD, FASCO

Ramaprasad Srinivasan, MD, PhD

Dharanija Rao

Chandler Park, MD, FACP

This session invites early-career healthcare professionals to discuss career opportunities in kidney cancer across academia, industry, private practice, and research. Engage with both emerging and experienced experts to exchange insights, experiences, and challenges, enriching your professional journey in the kidney cancer field.

Exhibits & Posters7:30 AM - 5:00 PMCommonwealth 6-8 
Session 1 Panel Discussion: 'Inoperable' Kidney Cancer8:10 AM - 9:30 AMCommonwealth 4-5

Moderators: Stephanie Berg,DO, Jodi Maranchie, MD

 

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Renal vein/thrombosus Involvement: Steven Chang, MD

 

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SAbR for Locally Advanced and Unresectable Primary RCC: Raquibul Hannan, MD, PhD

 

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Surveillance, Neoadjuvant / Palliative Treatment?: Leonard Appleman, MD, PhD

 

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Panel with cases and panel discussion.

 

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SESSION 2: Expanding Supportive Care Options to Improve the Patient Experience and Outcomes Before, During, and After Therapy9:30 AM - 10:30 AMCommonwealth 4-5

Moderators: Sarah Psutka, MD. MS, Viraj Master, Md, PhD, FACS

 

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Patient Perspective: Sid Sadler

 

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Integrative Oncology in Kidney Cancer: Viraj Master, MD, PhD, FACS

 

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Resilience Treatment & Burden Background Mindfulness/Wellness-based/Nutritional Interventions / Practices for Symptom / Toxicity Management: Anna Bausum, ND

 

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Management of Sleep, Fatigue, Distress from a Cognitive Neuroscience Perspective: David Sheppard, PhD/Sarah Psutka, MD. MS

 

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Exercise as Medicine: Hanna Hunter, MD

 

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Wrap-up: Highlights, CAM Trials: Sarah Psutka, MD, MS

 

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Moderated Q & A

Coffee Break10:30 AM - 10:50 AMCommonwealth 6-8 
SESSION 3: Divergent Histology in Kidney Cancer10:50 AM - 11:50 AMCommonwealth 4-5

Moderators: Jodi Maranchie, MD, Phillip M. Pierorazio, MD

 

Chromophobe Renal Cell Carcinoma: Novel Therapeutic Targets: Elizabeth (Lisa) Henske, MD, PhD

 

Presenter has requested their slides not be posted

 

WHO Definitions Divergent Path: Ying-Bei Chen, MD

 

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Current Options for RCC with Divergent Histology: Bradley McGregor,MD

 

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Ongoing Trials & Trials in the Pipeline: Benjamin Maughan, MD

 

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Moderated Q&A

SESSION 4: Oral Abstracts11:50 AM - 12:50 PMCommonwealth 4-5

Moderators: Priyanka Chablani, MD, Wenxin (Vincent) Xu, MD

Poster Ads
Lenvatinib plus pembrolizumab (L+P) vs sunitinib (S) in advanced renal cell carcinoma (aRCC): Patterns of progression and subsequent therapy in the CLEAR trial: Ulka N. Vaishampayan, MD

 

Blood-based multiomics profiling reveal immune features associated with response to immune checkpoint inhibitor (ICI) in patients with metastatic renal cell carcinoma (mRCC): Moshe C. Ornstein

 

99mTc-Sestamibi SPECT/CT for the Characterization of Solid Renal Masses: Secondary Endpoint Analysis of a Prospective Study Correlating Imaging to Histopathology Results: Aboubacar Kaba, MD

 

Body weight trajectories in patients with localized renal cell cancer: Linnea Olsson, PhD

 

Occurrence of local recurrences and metastases after ablative therapy versus partial nephrectomy of renal cell carcinoma: a real-world competing risk analysis: Prof Börje Ljungberg

 

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Oral Abstracts

 

Clonal Origin of Belzutifan-Resistant Kidney Tumors in VHL Disease: Alejandro Sanchez

 

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Transcript-Level Analysis Reveals Alternative Splicing and Isoform Switches in ccRCC: Implications for Progression and Survival: Chinaza Nnam

 

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TRAVERSE: Updated safety and efficacy of ALLO-316 in advanced/metastatic clear cell renal cell carcinoma (ccRCC): Ritesh Kotecha

 

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Validating Metastatic Organotropison of FGD1 Splice Varient in Clear Cell Renal Cell Carcinoma: Mitchell Hayes

 

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Moderated Q & A

Lunch12:50 PM - 2:10 PMCommonwealth 6-8

Grab lunch from the Exhibit Hall and bring it with you to the Merck industry session in Commonwealth 2-3.

Non-CME Symposium spnosored by Merck: Patient Case-Based Learning: Clinical Management of Certain Adult Patients With Advanced RCC1:00 PM - 2:00 PMCommonwealth 2-3

Learning Objectives:

•Understand clinical considerations for certain previously treated adult patients with advanced renal cell carcinoma.

•Review clinical data on a treatment option and how to sequence through a hypothetical patient case.

•Discuss how to monitor and manage potential adverse reactions through a hypothetical patient case.

 

Thai Ho, MD. has been caring for patients affected by genitourinary cancers for over 10 years. His expertise and the focus of his research is in treating kidney and bladder cancers. He also sees patients with kidney, bladder, upper tract urothelial, and prostate cancers, as well as patients affected by hereditary cancer syndromes. Dr Ho completed the Baylor College of Medicine Physician Scientist Program in 2006, internal medicine residency at Washington University in St. Louis in 2009, and Medical Oncology Fellowship at MD Anderson Cancer Center in 2012. At MUSC Hollings Cancer Center, Dr Ho is an Associate Professor, the Director of Precision Medicine, the Blatt-Ness Distinguished Endowed Chair in Cancer Research and a member of the Clinical Advisory Council for the VHL Alliance. Dr Ho comes to MUSC from the Mayo Clinic where he was an Associate Professor and a member of the Center for Individualized Medicine Epigenomics Group, Genomic Tumor Board, and von Hippel-Lindau Clinic. Grab lunch and bring it the session.

Break2:00 PM - 2:10 PMCommonwealth 4-5 
Session 5 Keynote Speaker2:10 PM - 2:40 PMCommonwealth 4-5

Introduction: Stephanie Berg, DO

Keynote: Targeting Metabolism: Beating Kidney Cancer at Its Own Game: M. Celeste Simon, PhD

Christopher G. Wood Rising Star Award2:40 PM - 2:55 PMCommonwealth 4-5

Introduction: Bradley C. Leibovich, MD

 

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Award Recipient: David Braun, MD, PhD

 

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SESSION 6: Going Beyond RECIST (Radiomics in Kidney Cancer)2:55 PM - 3:55 PMCommonwealth 4-5

Moderators: Yousef Zakharia, MD, Andrew Smith, MD, PhD

 

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Traditional Imaging Modalities: Andrew Smith, MD, PhD

 

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Challenges in Radiographics in Response to (Limitations of RECIST in Metastatic Setting): Simon Lo, MD, ChB, FACR, FASTRO

 

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Validation with the Machine Learning Algorithms: Irbaz Riaz, MD

 

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Moderated Q & A

Coffee Break3:55 PM - 4:05 PMCommonwealth 6-8 
SESSION 7: Mentorship Awards4:05 PM - 4:55 PMCommonwealth 4-5

Moderator: Brian Rini, MD, FASCO

 

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SETD2 Deficiency Confers Sensitivity to BCL-XL Inhibition: Aguirre De Cubas, PhD

 

Presenter has requested their slides not be posted

 

Investigating Decoy-Resistant IL-18 Plus Immune Checkpoint Inhibitors in Renal Cell Carcinoma + Moderated Q & A: David Schoenfield, MD, PhD

 

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Development of CA9-Targeted Radiopharmaceutical Agents for Kidney Cancer Theranostics: Reinier Hernandez, PhD

 

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Metabolic Transitions Governing Disease State in Clear Cell Renal Cell Carcinoma: Shuchi Gulati, MD, MS

 

Presenter has requested their slides not be posted

 

 

SESSION 8: Women & Allies in RCC: The Importance of Mentorship & Determining Your Career Path5:00 PM - 6:00 PMCommonwealth Ballroom 2 & 3

Moderators: Tian Zhang, MD, HHS, Ulka Vaishampayan, MD

Panelists: Julie Gralow, MD, FASP, FASCO, Naomi Haas, MD, Helen Moon, MD, Fatima Rangwala, MD, PhD, ELIzabeth (Lisa) Henske, MD, PhD

Women & Allies in RCC: Continuing the Conversation Networking Reception6:00 PM - 6:30 PMOld Louisville

Join Women in RCC members and others for a drink and light snacks to continue the conversation following Friday’s WiRCC session.

Networking Reception6:00 PM - 7:00 PMCommonwealth 6-8 
Poster Tour6:30 PM - 6:50 PMCommonwealth 6-8

Guides: Arpita Desai, Priyanka Chablani Meet in the Exhibit Hall

CME Symposium Presented by Peerview: Smart Steps for Effective Real-World Care in RCC: Enhancing Outcomes In Advanced Disease7:15 PM - 8:15 PMCommonwealth 2-3

Presenters: Sumanta Pal, Nizar Tannir, and Tian Zhang

Key Reasons to Attend
• Get expert insight on which patients with RCC may benefit from approved and emerging treatments based on the latest  evidence
• Hone your ability to sequence treatments throughout the advanced disease continuum
• Learn strategies for team-based AE mitigation and management to keep your patients receiving effective treatment as long as possible

This CME/MOC/AAPA activity is provided by PVI, PeerView Institute for Medical Education.
This educational activity is supported through independent medical education grants from AVEO Pharmaceuticals, Inc., Bristol Myers Squibb, Exelixis, Inc., and Merck & Co., Inc., Rahway, NJ, USA.

Saturday, November 9, 2024
Medical Steering Committee7:00 AM - 8:00 AMBarrelBy invitation only.
Registration Desk Open7:30 AM - 11:00 AM2nd Street Pre-function Hallway 
Exhibits & Posters7:30 AM - 11:00 AMCommonwealth 6-8 
Session 9 KCA Updates, Committee Recognition & Tumor board - Management of the SRM8:00 AM - 9:10 AMCommonwealth 4-5

KCA Updates: Salvatore LaRosa, PhD

 

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IKCSNA24 Committee Recognition

  • Stephanie A. Berg, DO
  • Jodi Maranchie, MD
  • Manojkumar Bupathi, MD, MS
  • Marie Carlo, MD
  • Daniel M. Geynisman, MD
  • Phillip M. Pierorazio, MD
  • Sarah Psutka, MD, MS
  • Yousef Zakharia, MD
  • Qing Zhang, PhD

Moderators: Phillip M. Pierorazio, MD, Brian Shuch, MD

DEBATE Triggers for Intervention for Patients on Active Surveillance: Tumor Size, Tumor Growth Rate, Tumor Histology: Maxine Tran, MD, Erick Kauffman, MD, Brian Shuch, MD

 

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View Shuch Presentation

 

Tumor Board: Suzanne Merrill, MD, FACS, Joseph Panaro, MD, Adam Olson, MD, Maxine Tran, MD

 

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SESSION 10: Patient-Centered Outcomes in Kidney Cancer Research9:10 AM - 10:00 AMCommonwealth 4-5

Moderators: Dena Battle, Dan Geynisman, MD

Patient Perspective COA: Katie Coleman

 

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Measuring and Mitigating Decision Regret in the Management of Kidney Cancer: Sarah Psutka, MD, MS

 

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Disease Burden in Renal Cell Carcinoma: Dena Battle

 

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Financial Toxity and QoL: David Cella, PhD

 

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Moderated Q & A

Coffee Break10:00 AM - 10:15 AMCommonwealth 6-8 
SESSION 11: Oral Abstracts10:15 AM - 11:00 AMCommonwealth 4-5

Moderators: Marie Carlo, MD, Yousef Zakharia, MD

A Phase I/ II Trial of Pazopanib (Paz) Alternating (alt) with Bevacizumab (Bev) in Treatment-naïve Metastatic Clear Cell Renal Cell Carcinoma (mccRCC) Patients (pts): Phase II results: Saby George, MD

 

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CANINE: Prospective Comparison of Contrast-Enhanced Computed Tomography Against 89-Zr-TLX250 PositroN Emission Tomography/Computed Tomography for the Imaging-Based DetectioN of REcurrent Clear Cell Renal Cell Carcinoma After Surgery: Brian Shuch, MD

 

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Characterization of the Safety Profile of Belzutifan in Patients With Renal Cell Carcinoma (RCC): A Pooled Analysis of 4 Clinical Trials: Pooja Ghatalia, MD

 

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Phase 1 Study of Sitravatinib Combined with Nivolumab and Ipilimumab in Patients with Advanced Clear Cell Renal Cell Carcinoma: Clinical Outcomes and Translational Correlatives: Pavlos Msaouel, MD

 

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SESSION 12: Beyond IO and TKI11:00 AM - 12:00 PMCommonwealth 4-5

Moderators: Manojkumar Bupathi, MD, MS,  Sumanta (Monty) Kumar Pal, MD, FASCO

 

HIF-2alpha: Kevin Courtney, MD, Phd

 

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Other Checkpoint Drugs: Naomi Haas, MD

 

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CAR-T Therapy: Ben Garmezy, MD

 

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Vaccines: Elizabeth (Betsy) Plimack, MD, MS

 

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Moderated Q & A

SESSION 13: WoodFire12:00 PM - 12:45 PMCommonwealth 4-5

Moderators: Brian Rini, MD, FASCO,  Brad Leibovich, MD

Panelists: Jose Karam, MD, FACS, Dan Geynisman, MD, Stephanie Berg, DO, E. Jason Abel, MD, FACS

SESSION 14: Awards Presentation12:45 PM - 1:10 PMCommonwealth 4-5

Introduction of Eugene P. Shonfeld Award Winner: Stephanie Berg, DO

 

Eugene P. Shonfeld Award Winner & Lecturer: Naomi Haas, MD

 

New Presentation

 

Introduction of Nicholas J. Voglezang Humanitarian Award Winner: Tian Zhang, MD

 

Nicholas J. Vogelzang Humanitarian Award Winner & Lecturer: Daniel J. George, MD

 

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Closing Comments1:10 PM - 1:15 PMCommonwealth 4-5

Closing Comments from Co-Chairs: Stephanie Berg, DO, Jodi Maranchie, MD

Grab & Go Lunch1:15 PM - 1:30 PMCommonwealth 4-5

Thank you for attending IKCSNA24!  A grab and go lunch available outside the general session room as you leave.

KCA Board of Directors Meeting2:00 PM - 5:00 PMBarrel

By invitation only.