Anne CALVEZ is a third-year PhD candidate at the Cordeliers Research Centre (INSERM, Paris, France), under the supervision of Pr Catherine Sautès-Fridman, Pr Hervé Fridman, and Pr Stéphane Oudard. Her thesis focuses on resistance to immune checkpoint inhibitors (ICI) in patients with metastatic clear cell renal cell carcinoma. She investigates the mechanisms driving the inhibition of anti-tumor immune responses implemented within Tertiary Lymphoid Structures (TLS), with particular emphasis on neuro-immune interactions.

Her research combines advanced techniques including multiplex and high-plex immunofluorescence imaging, bulk RNA sequencing, and spatial transcriptomics. The aim of her research is to identify novel biomarkers of resistance to ICI to improve patient stratification and uncover new therapeutic targets to enhance the effectiveness of immunotherapies and broaden patient responses.